Fujisawa Misa experiences premenstrual syndrome once a month. During those times, she tries to deal with her uncontrolled irritation at understanding her colleagues at work. One day, when she experiences PMS, her anger explodes at Yamazoe Takatoshi, who has recently begun working at the same company. It was just a small action that triggered her anger. She feels self-hatred because of this. Meanwhile, Yamazoe Takatoshi suffers from panic disorder. Due to that, he gave up on many things in his life and he carries a lethargic attitude to his life. Becoming aware of each other's situation, Yamazoe Takatoshi and Fujisawa Misa begin to share a bond and try to help each other. https://mydramalist.com/748321-yoake-no-subete